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Cleaved-Aggrecan (D369) Polyclonal Antibody
商品货号: PLA004317
适 应 性: 人,大鼠
WB IHC IF ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: ACAN
  • 蛋白名称: Aggrecan core protein
  • Human_gene_id: 176
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=176
  • Human_swiss_prot_no: P16112
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P16112/entry
  • Mouse_swiss_prot_no: Q61282
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q61282
  • Rat_gene_id: 58968
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58968
  • Rat_swiss_prot_no: P07897
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P07897
  • 特异性: Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: ACAN; AGC1; CSPG1; MSK16; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1
  • 实测条带: 44kD
  • 功能: alternative products:Additional isoforms seem to exist,developmental stage:Expression was detected in chondrocytes throughout the developing skeleton.,disease:Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.,domain:Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.,function:This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.,online information:Aggrecan,PTM:Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.,similarity:Belongs to the aggrecan/versican proteoglycan family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,similarity:Contains 4 Link domains.,subunit:Interacts with FBLN1.,tissue specificity:Restricted to cartilages.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Secreted, extracellular space, extracellular matrix .
  • 组织表达: Restricted to cartilages.
  • 科研货号: PLA004317
Cleaved-Aggrecan (D369) Polyclonal Antibody
Catalog No PLA004317
Product information
  • 基因名称: ACAN
  • 蛋白名称: Aggrecan core protein
  • Human_gene_id: 176
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=176
  • Human_swiss_prot_no: P16112
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P16112/entry
  • Mouse_swiss_prot_no: Q61282
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q61282
  • Rat_gene_id: 58968
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58968
  • Rat_swiss_prot_no: P07897
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P07897
  • 特异性: Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: ACAN; AGC1; CSPG1; MSK16; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1
  • 实测条带: 44kD
  • 功能: alternative products:Additional isoforms seem to exist,developmental stage:Expression was detected in chondrocytes throughout the developing skeleton.,disease:Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.,domain:Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.,function:This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.,online information:Aggrecan,PTM:Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.,similarity:Belongs to the aggrecan/versican proteoglycan family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,similarity:Contains 4 Link domains.,subunit:Interacts with FBLN1.,tissue specificity:Restricted to cartilages.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Secreted, extracellular space, extracellular matrix .
  • 组织表达: Restricted to cartilages.
  • 科研货号: PLA004317
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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