Cleaved-Aggrecan (D369) Polyclonal Antibody

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商品货号： PLA004317

适应性： 人,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： ACAN
蛋白名称： Aggrecan core protein
Human_gene_id： 176
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=176
Human_swiss_prot_no： P16112
Human_swiss_link： http://www.uniprot.org/uniprotkb/P16112/entry
Mouse_swiss_prot_no： Q61282
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61282
Rat_gene_id： 58968
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58968
Rat_swiss_prot_no： P07897
Rat_swiss_link： http://www.uniprot.org/uniprot/P07897
特异性： Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ACAN; AGC1; CSPG1; MSK16; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1
实测条带： 44kD
功能： alternative products:Additional isoforms seem to exist,developmental stage:Expression was detected in chondrocytes throughout the developing skeleton.,disease:Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.,domain:Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.,function:This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.,online information:Aggrecan,PTM:Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.,similarity:Belongs to the aggrecan/versican proteoglycan family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,similarity:Contains 4 Link domains.,subunit:Interacts with FBLN1.,tissue specificity:Restricted to cartilages.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted, extracellular space, extracellular matrix .
组织表达： Restricted to cartilages.
科研货号： PLA004317

Cleaved-Aggrecan (D369) Polyclonal Antibody

Catalog No PLA004317

Product information

基因名称： ACAN
蛋白名称： Aggrecan core protein
Human_gene_id： 176
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=176
Human_swiss_prot_no： P16112
Human_swiss_link： http://www.uniprot.org/uniprotkb/P16112/entry
Mouse_swiss_prot_no： Q61282
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61282
Rat_gene_id： 58968
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58968
Rat_swiss_prot_no： P07897
Rat_swiss_link： http://www.uniprot.org/uniprot/P07897
特异性： Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ACAN; AGC1; CSPG1; MSK16; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1
实测条带： 44kD
功能： alternative products:Additional isoforms seem to exist,developmental stage:Expression was detected in chondrocytes throughout the developing skeleton.,disease:Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.,domain:Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.,function:This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.,online information:Aggrecan,PTM:Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.,similarity:Belongs to the aggrecan/versican proteoglycan family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,similarity:Contains 4 Link domains.,subunit:Interacts with FBLN1.,tissue specificity:Restricted to cartilages.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted, extracellular space, extracellular matrix .
组织表达： Restricted to cartilages.
科研货号： PLA004317

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