Cleaved-Cathepsin D LC (G65) Polyclonal Antibody

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商品货号： PLA004313

适应性： 人,猴

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： CTSD
蛋白名称： Cathepsin D
Human_gene_id： 1509
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1509
Human_swiss_prot_no： P07339
Human_swiss_link： http://www.uniprot.org/uniprotkb/P07339/entry
Mouse_swiss_prot_no： P18242
Mouse_swiss_link： http://www.uniprot.org/uniprot/P18242
特异性： Cleaved-Cathepsin D LC (G65) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D LC protein resulting from cleavage adjacent to G65.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CTSD; CPSD; Cathepsin D
实测条带： 17kD
信号通路： Lysosome;
功能： catalytic activity:Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.,disease:Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.,function:Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.,polymorphism:The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.,similarity:Belongs to the peptidase A1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Consists of a light chain and a heavy chain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .
组织表达： Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
科研货号： PLA004313

Cleaved-Cathepsin D LC (G65) Polyclonal Antibody

Catalog No PLA004313

Product information

基因名称： CTSD
蛋白名称： Cathepsin D
Human_gene_id： 1509
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1509
Human_swiss_prot_no： P07339
Human_swiss_link： http://www.uniprot.org/uniprotkb/P07339/entry
Mouse_swiss_prot_no： P18242
Mouse_swiss_link： http://www.uniprot.org/uniprot/P18242
特异性： Cleaved-Cathepsin D LC (G65) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D LC protein resulting from cleavage adjacent to G65.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CTSD; CPSD; Cathepsin D
实测条带： 17kD
信号通路： Lysosome;
功能： catalytic activity:Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.,disease:Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.,function:Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.,polymorphism:The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.,similarity:Belongs to the peptidase A1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Consists of a light chain and a heavy chain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .
组织表达： Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
科研货号： PLA004313

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