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Cleaved-Cathepsin D LC (G65) Polyclonal Antibody
商品货号: PLA004313
适 应 性: 人,猴
WB ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: CTSD
  • 蛋白名称: Cathepsin D
  • Human_gene_id: 1509
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1509
  • Human_swiss_prot_no: P07339
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P07339/entry
  • Mouse_swiss_prot_no: P18242
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P18242
  • 特异性: Cleaved-Cathepsin D LC (G65) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D LC protein resulting from cleavage adjacent to G65.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: CTSD; CPSD; Cathepsin D
  • 实测条带: 17kD
  • 信号通路: Lysosome;
  • 功能: catalytic activity:Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.,disease:Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.,function:Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.,polymorphism:The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.,similarity:Belongs to the peptidase A1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Consists of a light chain and a heavy chain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .
  • 组织表达: Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
  • 科研货号: PLA004313
Cleaved-Cathepsin D LC (G65) Polyclonal Antibody
Catalog No PLA004313
Product information
  • 基因名称: CTSD
  • 蛋白名称: Cathepsin D
  • Human_gene_id: 1509
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1509
  • Human_swiss_prot_no: P07339
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P07339/entry
  • Mouse_swiss_prot_no: P18242
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P18242
  • 特异性: Cleaved-Cathepsin D LC (G65) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D LC protein resulting from cleavage adjacent to G65.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: CTSD; CPSD; Cathepsin D
  • 实测条带: 17kD
  • 信号通路: Lysosome;
  • 功能: catalytic activity:Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.,disease:Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.,function:Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.,polymorphism:The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.,similarity:Belongs to the peptidase A1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Consists of a light chain and a heavy chain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .
  • 组织表达: Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
  • 科研货号: PLA004313
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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