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Cleaved-C1s HC (R437) Polyclonal Antibody
商品货号: PLA004299
适 应 性: 人,大鼠,小鼠,
WB ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: C1S
  • 蛋白名称: Complement C1s subcomponent
  • Human_gene_id: 716
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=716
  • Human_swiss_prot_no: P09871
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P09871/entry
  • 特异性: Cleaved-C1s HC (R437) Polyclonal Antibody detects endogenous levels of fragment of activated C1s HC protein resulting from cleavage adjacent to R437.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: C1S; Complement C1s subcomponent; C1 esterase; Complement component 1 subcomponent s
  • 实测条带: 47+76kD
  • 信号通路: Complement and coagulation cascades;Systemic lupus erythematosus;
  • 功能: catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.,disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580]; that is associated with early onset multiple autoimmune diseases.,enzyme regulation:Inhibited by SERPING1.,function:C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.,online information:C1S mutation db,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: extracellular region,extracellular exosome,blood microparticle,
  • 组织表达: Liver,Peripheral blood leukocyte,Plasma,PNS,
  • 科研货号: PLA004299
Cleaved-C1s HC (R437) Polyclonal Antibody
Catalog No PLA004299
Product information
  • 基因名称: C1S
  • 蛋白名称: Complement C1s subcomponent
  • Human_gene_id: 716
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=716
  • Human_swiss_prot_no: P09871
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P09871/entry
  • 特异性: Cleaved-C1s HC (R437) Polyclonal Antibody detects endogenous levels of fragment of activated C1s HC protein resulting from cleavage adjacent to R437.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: C1S; Complement C1s subcomponent; C1 esterase; Complement component 1 subcomponent s
  • 实测条带: 47+76kD
  • 信号通路: Complement and coagulation cascades;Systemic lupus erythematosus;
  • 功能: catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.,disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580]; that is associated with early onset multiple autoimmune diseases.,enzyme regulation:Inhibited by SERPING1.,function:C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.,online information:C1S mutation db,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: extracellular region,extracellular exosome,blood microparticle,
  • 组织表达: Liver,Peripheral blood leukocyte,Plasma,PNS,
  • 科研货号: PLA004299
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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