Cleaved-C1s HC (R437) Polyclonal Antibody

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商品货号： PLA004299

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： C1S
蛋白名称： Complement C1s subcomponent
Human_gene_id： 716
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=716
Human_swiss_prot_no： P09871
Human_swiss_link： http://www.uniprot.org/uniprotkb/P09871/entry
特异性： Cleaved-C1s HC (R437) Polyclonal Antibody detects endogenous levels of fragment of activated C1s HC protein resulting from cleavage adjacent to R437.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： C1S; Complement C1s subcomponent; C1 esterase; Complement component 1 subcomponent s
实测条带： 47+76kD
信号通路： Complement and coagulation cascades;Systemic lupus erythematosus;
功能： catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.,disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580]; that is associated with early onset multiple autoimmune diseases.,enzyme regulation:Inhibited by SERPING1.,function:C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.,online information:C1S mutation db,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： extracellular region,extracellular exosome,blood microparticle,
组织表达： Liver,Peripheral blood leukocyte,Plasma,PNS,
科研货号： PLA004299

Cleaved-C1s HC (R437) Polyclonal Antibody

Catalog No PLA004299

Product information

基因名称： C1S
蛋白名称： Complement C1s subcomponent
Human_gene_id： 716
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=716
Human_swiss_prot_no： P09871
Human_swiss_link： http://www.uniprot.org/uniprotkb/P09871/entry
特异性： Cleaved-C1s HC (R437) Polyclonal Antibody detects endogenous levels of fragment of activated C1s HC protein resulting from cleavage adjacent to R437.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： C1S; Complement C1s subcomponent; C1 esterase; Complement component 1 subcomponent s
实测条带： 47+76kD
信号通路： Complement and coagulation cascades;Systemic lupus erythematosus;
功能： catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.,disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580]; that is associated with early onset multiple autoimmune diseases.,enzyme regulation:Inhibited by SERPING1.,function:C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.,online information:C1S mutation db,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： extracellular region,extracellular exosome,blood microparticle,
组织表达： Liver,Peripheral blood leukocyte,Plasma,PNS,
科研货号： PLA004299

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