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Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody
商品货号: PLA004288
适 应 性: 人,小鼠,大鼠
WB IHC IF ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: CASP3
  • 蛋白名称: Caspase3
  • Human_gene_id: 836
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=836
  • Human_swiss_prot_no: P42574
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P42574/entry
  • Mouse_gene_id: 12367
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12367
  • Mouse_swiss_prot_no: P70677
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P70677
  • Rat_gene_id: 25402
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25402
  • Rat_swiss_prot_no: P55213
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P55213
  • 特异性: Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-3 p17 protein resulting from cleavage adjacent to D175.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
  • 实测条带: 17 34kD
  • 信号通路: MAPK_ERK_Growth;MAPK_G_Protein;p53;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Natural killer cell mediated cytotoxicity;Alzheimer's disease;Parkinson's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Colorectal cancer;Viral myocarditis;
  • 功能: catalytic activity:Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.,enzyme regulation:Inhibited by isatin sulfonamides.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.,PTM:Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.,PTM:S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.,similarity:Belongs to the peptidase C14A family.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.,tissue specificity:Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm.
  • 组织表达: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
  • tag: hot
  • 科研货号: PLA004288
Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody
Catalog No PLA004288
Product information
  • 基因名称: CASP3
  • 蛋白名称: Caspase3
  • Human_gene_id: 836
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=836
  • Human_swiss_prot_no: P42574
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P42574/entry
  • Mouse_gene_id: 12367
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12367
  • Mouse_swiss_prot_no: P70677
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P70677
  • Rat_gene_id: 25402
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25402
  • Rat_swiss_prot_no: P55213
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P55213
  • 特异性: Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-3 p17 protein resulting from cleavage adjacent to D175.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
  • 实测条带: 17 34kD
  • 信号通路: MAPK_ERK_Growth;MAPK_G_Protein;p53;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Natural killer cell mediated cytotoxicity;Alzheimer's disease;Parkinson's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Colorectal cancer;Viral myocarditis;
  • 功能: catalytic activity:Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.,enzyme regulation:Inhibited by isatin sulfonamides.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.,PTM:Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.,PTM:S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.,similarity:Belongs to the peptidase C14A family.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.,tissue specificity:Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm.
  • 组织表达: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
  • tag: hot
  • 科研货号: PLA004288
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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